About the Study

Study to Clinically describe ALdosterone Dysregulation (SCALED):
This study will enroll a subset of a larger cohort study for prospective data collection. Approximately 500 individuals with hypertension will be invited and consented to participate in a clinical examination consisting of blood pressure and body composition measurements and blood and urine specimen collection.

Study Goal

This study aims to better understand how a hormone called aldosterone affects high blood pressure to help improve diagnosis, treatment, and blood pressure control.

SCALED Study Objectives

To identify patient and clinical factors that may help predict aldosterone-related problems.
To understand how a hormone called aldosterone changes over time in people with high blood pressure and how it relates to common health measures like blood pressure and lab results.
To describe the health and demographic characteristics of people with high blood pressure, both with and without aldosterone-related issues.

Study Population

Who Qualifies to Participate? (Inclusion Criteria)

Participants will include men and women ≥ 18 years of age with established high blood pressure
Consented to participate in the study
Willingness and ability to complete additional assessments

Who Does Not Qualify to Participate (Exclusion Criteria)

Only hypertension during pregnancy
Diagnosed cause of secondary hypertension from drug or alcohol induced, or renovascular hypertension1
Bariatric surgery or GLP1 prescription in the last 12 months
Exposure to an aldosterone synthase inhibitor or a mineralocorticoid receptor antagonist in the past 12 weeks
Last known estimated glomerular filtration rate < 45 mL/min/1.73m2 (according to the CKD-EPI equation) at the time of screening
- Kidney transplant
- Currently receiving dialysis
- Current enrollment in any cardiovascular or blood pressure trial

Division of Research
4480 Hacienda Drive
Pleasanton, CA 94588

Toll Free Number: (833) 544-7289
Email: ScaledStudy@kp.org